Sample size re-estimation for adaptive sequential design in clinical trials.
نویسندگان
چکیده
There is considerable interest in methods that use accumulated data to modify trial sample size. However, sample size re-estimation in group sequential designs has been controversial. We describe a method for sample size re-estimation at the penultimate stage of a group sequential design that achieves specified power against an alternative hypothesis corresponding to the current point estimate of the treatment effect.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of biopharmaceutical statistics
دوره 18 6 شماره
صفحات -
تاریخ انتشار 2008